Commit d58554ef authored by Christian Arnold's avatar Christian Arnold
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Updated various parts, mostly Documentation

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Genome-wide quantification of differential transcription factor activity: diffTF
Transcription factor (TF) activity constitutes an important readout of cellular signalling pathways and thus for assessing regulatory differences across conditions. However, current technologies lack the ability to simultaneously assessing activity changes for multiple TFs and surprisingly little is known about whether a TF acts as repressor or activator. To this end, we introduce the widely applicable genome-wide method diffTF to assess differential TF binding activity and classifying TFs as activator or repressor by integrating any type of genome-wide chromatin with RNA-Seq data and in-silico predicted TF binding sites
Instructions to run the example analysis
Change into the example/input directory within the Git repository
``cd diffTF/example/input``
Download the data via the download script
Start a dryrun via the helper script
Once the dryrun is successful, change the script and remove the dryrun directive to start the analysis and restart the script.
*Please cite the following article if you use diffTF in your research*:
* Ivan Berest*, Christian Arnold*, Armando Reyes-Palomares, Kasper Rassmussen & Judith B. Zaugg. Genome-wide quantification of differential transcription factor activity: diffTF. 2017. submitted.
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"outdir" : "output",
"outdir" : "../output",
"regionExtension" : 100,
"comparisonType" : "GMPvsMPP",
"designContrast" : "~ conditionSummary",
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