diff --git a/model_server/base/accessors.py b/model_server/base/accessors.py
index 07eba484b24c7b64b729ee1bb71de708ecf1f934..b0df05873d982be7b9578bebdab47ad5dd13b1c8 100644
--- a/model_server/base/accessors.py
+++ b/model_server/base/accessors.py
@@ -162,6 +162,14 @@ class CziImageFileAccessor(GenericImageFileAccessor):
         except Exception:
             raise FileAccessorError(f'Unable to access CZI data in {fpath}')
 
+        try:
+            md = cf.metadata(raw=False)
+            compmet = md['ImageDocument']['Metadata']['Information']['Image']['OriginalCompressionMethod']
+        except KeyError:
+            raise InvalidCziCompression('Could not find metadata key OriginalCompressionMethod')
+        if compmet.upper() != 'UNCOMPRESSED':
+            raise InvalidCziCompression(f'Unsupported compression method {compmet}')
+
         sd = {ch: cf.shape[cf.axes.index(ch)] for ch in cf.axes}
         if (sd.get('S') and (sd['S'] > 1)) or (sd.get('T') and (sd['T'] > 1)):
             raise DataShapeError(f'Cannot handle image with multiple positions or time points: {sd}')
@@ -345,6 +353,9 @@ class FileWriteError(Error):
 class InvalidAxisKey(Error):
     pass
 
+class InvalidCziCompression(Error):
+    pass
+
 class InvalidDataShape(Error):
     pass