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LocScale is a reference-based local amplitude scaling tool that used prior model information to improve contrast of cryo-EM density maps.
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To reliably reflect the required level of local sharpening and local resolution variation in the target map, the model used for scaling should have refined B-factors using appropriate protocols.
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<br>
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<br>
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<img src="https://git.embl.de/jakobi/LocScale/raw/master/doc/img/EM_cyle_DM_1.jpg" width="400">
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