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LocScale is a reference-based local amplitude scaling tool that used prior model information to improve contrast of cryo-EM density maps.
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The LocScale methods
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<img src="https://git.embl.de/jakobi/LocScale/raw/master/doc/img/EM_cyle_DM_1.jpg" width="400">
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The method is described in detail in a [BioRxiv](https://doi.org/10.1101/121913) preprint
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The method is described in detail in a [BioRxiv](https://doi.org/10.1101/121913) preprint.
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Below are links to further documentation for local amplitude scaling ([__LocScale__](LocScale)) and our in-house local resolution estimation routine ([__LocRes__](LocRes)).
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[__LocRes__](LocRes) - local resolution estimation based on windowed FSC calculation
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[__LocScale__](LocScale) - local sharpening based on reference-based amplitude scaling
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