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Commit d08bbe6c authored by Malvika Sharan's avatar Malvika Sharan
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Update multiple_sequence_alignment.md

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......@@ -21,13 +21,11 @@ Input: It requires protein accession IDs or protein seqences in FASTA format.
[Frequently asked questions](http://www.ebi.ac.uk/Tools/msa/clustalo/help/faq.html#1)
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What substitution matrix/default parameters are used by Clustal Omega?
`What substitution matrix/default parameters are used by Clustal Omega?
Clustal Omega uses the HHalign algorithm and its default settings as its core alignment engine. The algorithm is described in Söding, J. (2005) 'Protein homology detection by HMM–HMM comparison'. Bioinformatics 21, 951-960.
The default transition matrix is Gonnet, gap opening penalty is 6 bits, gap extension is 1 bit.
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The default transition matrix is Gonnet, gap opening penalty is 6 bits, gap extension is 1 bit.`
### Examples:
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