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Commit 4bc273a6 authored by Malvika Sharan's avatar Malvika Sharan
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Update tertiary_structure_pred.md

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......@@ -120,11 +120,20 @@ Note the PhyreAlarm icon. This pops up in such cases of low confidence and cover
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
````
Full html results of all homologues, models, secondary structure and more available at:
Full html results of all homologues, models, secondary structure etc. available at:
http://www.sbg.bio.ic.ac.uk/phyre2/phyre2_output/ecba3197e3730bcd/summary.html
***Example using Human Toll like receptor***
````
>sp|Q15399|TLR1_HUMAN Toll-like receptor 1 OS=Homo sapiens GN=TLR1 PE=1 SV=3
MTSIFHFAIIFMLILQIRIQLSEESEFLVDRSKNGLIHVPKDLSQKTTILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKLVKISCHPTVNLKHLDLSFNAFDALPICKEFGNMSQLKFLGLSTTHLEKSSVLPIAHLNISKVLLVLGETYGEKEDPEGLQDFNTESLHIVFPTNKEFHFILDVSVKTVANLELSNIKCVLEDNKCSYFLSILAKLQTNPKLSNLTLNNIETTWNSFIRILQLVWHTTVWYFSISNVKLQGQLDFRDFDYSGTSLKALSIHQVVSDVFGFPQSYIYEIFSNMNIKNFTVSGTRMVHMLCPSKISPFLHLDFSNNLLTDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSNILTDTIFRCLPPRIKVLDLHSNKIKSIPKQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELGEFVKNIDQVSSEVLEGWPDSYKCDYPESYRGTLLKDFHMSELSCNITLLIVTIVATMLVLAVTVTSLCSYLDLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYSGHDSFWVKNELLPNLEKEGMQICLHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNSLILILLEPIPQYSIPSSYHKLKSLMARRTYLEWPKEKSKRGLFWANLRAAINIKLTEQAKK
````
Full html results of all homologues, models, secondary structure etc. available at:
http://www.sbg.bio.ic.ac.uk/phyre2/phyre2_output/6f4f568f92839199/summary.html
###### Example of intensive analysis: http://www.sbg.bio.ic.ac.uk/phyre2/phyre2_output/d4a1f7b1ec99b495/summary.html
1.Click the Interactive 3D view in JSmol link. Maybe that N-terminal blue alpha-helix (which was built ab initio) probably shouldn't be where it is. It should probably pack better - but ab initio is tricky! Also there appears to be some tangling in the red C-terminus. This is usually caused by disagreements between the input templates in that region.
......@@ -142,7 +151,7 @@ Intensive mode often creates excellent full length models that cannot be achieve
**Other tools**:
Example used: Human Toll like receptor 4
Example: Human Toll like receptor 4
````
>sp|O00206|TLR4_HUMAN Toll-like receptor 4 OS=Homo sapiens GN=TLR4 PE=1 SV=2
......@@ -162,12 +171,16 @@ NIIHEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKTLLR
QQVELYRLLSRNTYLEWEDSVLGRHIFWRRLRKALLDGKSWNPEGTVGTGCNWQEATSI
````
1. [I-TASSER](http://zhanglab.ccmb.med.umich.edu/I-TASSER/)
Requires registration and submission permission
Check an already analysed result page for [Toll like receptor 4](http://www.uniprot.org/uniprot/O00206) using I-TASSER
Results available at: http://zhanglab.ccmb.med.umich.edu/I-TASSER/output/S298631/
1. (PS)2-v2: [Protein Structure Prediction Server](http://ps2.life.nctu.edu.tw/docs.php)
- A much faster tool compared the Phyre2
- A much faster tool compared the Phyre2, unfortunately broken at the moment.
- combines both sequence and secondary structure information for the detection of homologous proteins with remote similarity and the target-template alignment.
- Check an already analysed result page for [Toll like receptor 4](http://www.uniprot.org/uniprot/O00206) using (PS)2-v2
2. [I-TASSER](http://zhanglab.ccmb.med.umich.edu/I-TASSER/)
Requires registration and submission permission
Check an already analysed result page for [Toll like receptor 4](http://www.uniprot.org/uniprot/O00206) using I-TASSER
Results available at: http://140.113.239.111/~ps2v2/display_multi.php?folder=408053421
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